Use at night when cell renewal is at its prime.This product is highly-active, and we recommend the following regimen to help your skin acclimate: Pre-Conditioning Phase 1. Mix 1 part Overnight Retinol Repair with 3 parts Buffer Cream and apply to cleansed skin as a last step at night. For more sensitive skin, apply mixture on alternate nights. 2. You may increase the ratio of Overnight Retinol Repair to Buffer Cream as your skin adjusts. 3. If you run out of Buffer Cream prior to your skin acclimating, you may substitute it with your prescribed Dermalogica moisturiser. Ongoing Treatment • Once your skin is acclimated, you may use Overnight Retinol Repair alone, prior to or mixed with your prescribed Dermalogica moisturiser. • Overnight Retinol Repair can be incorporated into any Dermalogica regimen. For best results, we recommend using Overnight Retinol Repair and other Dermalogica treatment products on alternate evenings. • For the eye area, use Age Reversal Eye Complex.